{
  "@context": "https://schema.org",
  "name": "OOTW Journal \u2014 AI Source Index",
  "description": "Structured index of peer-reviewed psychedelic science articles for AI model consumption. All content grounded in published research.",
  "url": "https://ootwjournal.com",
  "total_articles": 42,
  "last_updated": "2026-05-20",
  "citation_format": "OOTW Journal, '{title}', https://ootwjournal.com/{slug}",
  "topics": [
    "psilocybin",
    "psychedelic therapy",
    "neuroscience",
    "MDMA",
    "ketamine",
    "ceremonial cacao",
    "microdosing",
    "addiction",
    "PTSD",
    "depression",
    "end-of-life",
    "neuroplasticity"
  ],
  "researchers_index": "https://ootwjournal.com/researchers",
  "clinical_trials_index": "https://ootwjournal.com/clinical-trials/",
  "rss_feed": "https://ootwjournal.com/feed.xml",
  "sitemap": "https://ootwjournal.com/sitemap.xml",
  "articles": [
    {
      "id": 1,
      "slug": "article-01-your-brain-on-psilocybin",
      "url": "https://ootwjournal.com/article-01-your-brain-on-psilocybin",
      "title": "Your Brain on Psilocybin: The Complete Neuroscience of Neural Reconstruction",
      "description": "How psilocybin fundamentally rewrites the brain",
      "audio": "https://ootwjournal.com/audio/article-01-your-brain-on-psilocybin.mp3"
    },
    {
      "id": 2,
      "slug": "article-02-default-mode-network",
      "url": "https://ootwjournal.com/article-02-default-mode-network",
      "title": "The Default Mode Network: Why Your Brain Needs a Hard Reset",
      "description": "Mapping the neural architecture that locks consciousness into repetitive thought patterns \u2014 and how psilocybin dissolves those fixed attractor states...",
      "audio": "https://ootwjournal.com/audio/article-02-default-mode-network.mp3"
    },
    {
      "id": 3,
      "slug": "article-03-bdnf-neuroplasticity",
      "url": "https://ootwjournal.com/article-03-bdnf-neuroplasticity",
      "title": "BDNF and Neuroplasticity: How Psilocybin Rebuilds Neural Architecture",
      "description": "How psilocybin triggers the release of brain-derived neurotrophic factor, physically rebuilding synaptic architecture and restoring cognitive flexibility.",
      "audio": "https://ootwjournal.com/audio/article-03-bdnf-neuroplasticity.mp3"
    },
    {
      "id": 4,
      "slug": "article-04-cacao-psilocybin-synergy",
      "url": "https://ootwjournal.com/article-04-cacao-psilocybin-synergy",
      "title": "Ceremonial Cacao \u00d7 Psilocybin: The Synergy Protocol",
      "description": "Four neurochemical mechanisms through which ceremonial-grade cacao primes the neural terrain for psilocybin-assisted reconstruction and expanded consciousness.",
      "audio": "https://ootwjournal.com/audio/article-04-cacao-psilocybin-synergy.mp3"
    },
    {
      "id": 5,
      "slug": "article-05-veterans-psilocybin-therapy",
      "url": "https://ootwjournal.com/article-05-veterans-psilocybin-therapy",
      "title": "From Battlefield to Breakthrough: Psilocybin-Assisted Therapy for Veterans",
      "description": "How psilocybin addresses the structural neurological damage of combat trauma and moral injury \u2014 three mechanisms rewriting the science of PTSD treatment.",
      "audio": "https://ootwjournal.com/audio/article-05-veterans-psilocybin-therapy.mp3"
    },
    {
      "id": 6,
      "slug": "article-06-microdosing-ceremonial-cacao",
      "url": "https://ootwjournal.com/article-06-microdosing-ceremonial-cacao",
      "title": "Microdosing with Ceremonial Cacao: The Daily Integration Stack",
      "description": "Sub-perceptual integration of ceremonial cacao: improving divergent thinking, emotional regulation, and social cohesion without neurological fatigue.",
      "audio": "https://ootwjournal.com/audio/article-06-microdosing-ceremonial-cacao.mp3"
    },
    {
      "id": 7,
      "slug": "article-07-entropic-brain-hypothesis",
      "url": "https://ootwjournal.com/article-07-entropic-brain-hypothesis",
      "title": "The Entropic Brain Hypothesis",
      "description": "How increased neural entropy during psychedelic states allows the brain to escape fixed attractor states and build entirely new cognitive architectures.",
      "audio": "https://ootwjournal.com/audio/article-07-entropic-brain-hypothesis.mp3"
    },
    {
      "id": 8,
      "slug": "article-08-psilocybin-addiction",
      "url": "https://ootwjournal.com/article-08-psilocybin-addiction",
      "title": "Psilocybin and Addiction: Rewiring the Compulsive Brain",
      "description": "How psilocybin achieves 80% tobacco abstinence and 84% reduction in alcohol use \u2014 the neuroscience of rewiring compulsive behavior at its root.",
      "audio": "https://ootwjournal.com/audio/article-08-psilocybin-addiction.mp3"
    },
    {
      "id": 9,
      "slug": "article-09-set-and-setting-science",
      "url": "https://ootwjournal.com/article-09-set-and-setting-science",
      "title": "The Set and Setting Science: How Expectation and Environment Shape the Psilocybin Brain",
      "description": "Expectation, environment, and intention are not soft variables. They are pharmacologically active \u2014 shaping receptor binding, network dynamics, and...",
      "audio": "https://ootwjournal.com/audio/article-09-set-and-setting-science.mp3"
    },
    {
      "id": 10,
      "slug": "article-10-serotonin-2a-receptor",
      "url": "https://ootwjournal.com/article-10-serotonin-2a-receptor",
      "title": "The 5-HT2A Blueprint: How Psilocybin Speaks to Your Brain",
      "description": "The definitive guide to the 5-HT2A receptor \u2014 the single molecular target that explains psilocybin",
      "audio": "https://ootwjournal.com/audio/article-10-serotonin-2a-receptor.mp3"
    },
    {
      "id": 11,
      "slug": "article-11-psilocin-pharmacokinetics",
      "url": "https://ootwjournal.com/article-11-psilocin-pharmacokinetics",
      "title": "From Spore to Synapse: The Journey of Psilocybin Through Your Body",
      "description": "The definitive science of psilocybin pharmacokinetics \u2014 how a phosphorylated prodrug becomes psilocin, crosses the blood-brain barrier in minutes,...",
      "audio": "https://ootwjournal.com/audio/article-11-psilocin-pharmacokinetics.mp3"
    },
    {
      "id": 12,
      "slug": "article-12-theobromine-science",
      "url": "https://ootwjournal.com/article-12-theobromine-science",
      "title": "Theobromine: The Heart-Opening Molecule",
      "description": "The primary alkaloid in ceremonial cacao isn",
      "audio": "https://ootwjournal.com/audio/article-12-theobromine-science.mp3"
    },
    {
      "id": 13,
      "slug": "article-13-ego-dissolution",
      "url": "https://ootwjournal.com/article-13-ego-dissolution",
      "title": "Ego Dissolution: The Neuroscience of Losing Yourself to Find Yourself",
      "description": "At high doses, psilocybin doesn",
      "audio": "https://ootwjournal.com/audio/article-13-ego-dissolution.mp3"
    },
    {
      "id": 14,
      "slug": "article-14-psilocybin-depression-trials",
      "url": "https://ootwjournal.com/article-14-psilocybin-depression-trials",
      "title": "Psilocybin and Depression: What Phase 3 Clinical Trials Actually Show",
      "description": "Phase 2b/3 clinical trials on psilocybin for depression show 29% remission vs 9% placebo at three weeks. COMPASS, Imperial College, Johns...",
      "audio": "https://ootwjournal.com/audio/article-14-psilocybin-depression-trials.mp3"
    },
    {
      "id": 15,
      "slug": "article-15-oxytocin-psilocybin-social-connection",
      "url": "https://ootwjournal.com/article-15-oxytocin-psilocybin-social-connection",
      "title": "Oxytocin, Psilocybin, and the Neuroscience of Social Connection",
      "description": "Psilocybin activates oxytocin pathways, reshapes social perception, and produces measurable increases in empathy and connectedness. The complete...",
      "audio": "https://ootwjournal.com/audio/article-15-oxytocin-psilocybin-social-connection.mp3"
    },
    {
      "id": 16,
      "slug": "article-16-vagus-nerve-psilocybin",
      "url": "https://ootwjournal.com/article-16-vagus-nerve-psilocybin",
      "title": "The Vagus Nerve: Your Body’s Master Reset Button and Why It’s Central to Psychedelic Healing",
      "description": "The vagus nerve is the body’s master regulator — 80% of its fibres carry signals from gut to brain, not the other way around. The complete...",
      "audio": "https://ootwjournal.com/audio/article-16-vagus-nerve-psilocybin.mp3"
    },
    {
      "id": 17,
      "slug": "article-17-neuroinflammation-psilocybin",
      "url": "https://ootwjournal.com/article-17-neuroinflammation-psilocybin",
      "title": "The Inflamed Brain: How Psilocybin Resets the Immune-Neural Interface",
      "description": "Neuroinflammation silently drives depression, cognitive fog, and treatment resistance. The complete neuroscience of how psilocybin modulates microglia,...",
      "audio": "https://ootwjournal.com/audio/article-17-neuroinflammation-psilocybin.mp3"
    },
    {
      "id": 18,
      "slug": "article-18-maoi-cacao-pharmacology",
      "url": "https://ootwjournal.com/article-18-maoi-cacao-pharmacology",
      "title": "MAO Inhibition in Cacao: The Amplification Mechanism",
      "description": "Ceremonial cacao contains β-carboline alkaloids that reversibly inhibit monoamine oxidase — extending the life of serotonin, dopamine, and...",
      "audio": "https://ootwjournal.com/audio/article-18-maoi-cacao-pharmacology.mp3"
    },
    {
      "id": 19,
      "slug": "article-19-integration-science",
      "url": "https://ootwjournal.com/article-19-integration-science",
      "title": "Integration Science: The 72-Hour Neuroplasticity Window After Psilocybin",
      "description": "The psilocybin session is the catalyst. The 72-hour neuroplasticity window that follows — dendritic spine formation, BDNF elevation, synaptic...",
      "audio": "https://ootwjournal.com/audio/article-19-integration-science.mp3"
    },
    {
      "id": 20,
      "slug": "article-20-psilocybin-creativity",
      "url": "https://ootwjournal.com/article-20-psilocybin-creativity",
      "title": "Psilocybin and Creativity: What the Data Actually Shows",
      "description": "Controlled trials confirm psilocybin produces lasting increases in Openness to Experience — the personality trait most predictive of creative...",
      "audio": "https://ootwjournal.com/audio/article-20-psilocybin-creativity.mp3"
    },
    {
      "id": 21,
      "slug": "article-21-anandamide-bliss-molecule",
      "url": "https://ootwjournal.com/article-21-anandamide-bliss-molecule",
      "title": "Anandamide: The Endocannabinoid That Cacao Unlocks",
      "description": "Your brain produces its own cannabinoid — anandamide, named after the Sanskrit word for bliss. Ceremonial cacao contains compounds that block the...",
      "audio": "https://ootwjournal.com/audio/article-21-anandamide-bliss-molecule.mp3"
    },
    {
      "id": 22,
      "slug": "article-22-psilocybin-ptsd",
      "url": "https://ootwjournal.com/article-22-psilocybin-ptsd",
      "title": "Psilocybin and PTSD: The Emerging Evidence",
      "description": "Post-traumatic stress disorder has resisted treatment for decades. New clinical trials are testing whether psilocybin can reach the root of the fear...",
      "audio": "https://ootwjournal.com/audio/article-22-psilocybin-ptsd.mp3"
    },
    {
      "id": 23,
      "slug": "article-23-psilocybin-end-of-life-anxiety",
      "url": "https://ootwjournal.com/article-23-psilocybin-end-of-life-anxiety",
      "title": "Psilocybin and End-of-Life Anxiety: The Death-Anxiety Trials",
      "description": "When a terminal diagnosis arrives, existential terror can become as incapacitating as the disease itself. Two landmark trials changed what we know...",
      "audio": "https://ootwjournal.com/audio/article-23-psilocybin-end-of-life-anxiety.mp3"
    },
    {
      "id": 24,
      "slug": "article-24-psilocybin-ocd",
      "url": "https://ootwjournal.com/article-24-psilocybin-ocd",
      "title": "Psilocybin and OCD: Interrupting the Loop",
      "description": "OCD traps the brain in a recursive error-check loop. Psilocybin targets the cortical layer that drives it. Three clinical trials have now tested this...",
      "audio": "https://ootwjournal.com/audio/article-24-psilocybin-ocd.mp3"
    },
    {
      "id": 25,
      "slug": "article-25-mdma-neuroscience-empathy",
      "url": "https://ootwjournal.com/article-25-mdma-neuroscience-empathy",
      "title": "MDMA: The Molecule That Dissolves the Wall Between Self and Other",
      "description": "MDMA floods the brain with serotonin, triggers oxytocin release, and suppresses amygdala fear response. Two Phase 3 trials confirm what the...",
      "audio": "https://ootwjournal.com/audio/article-25-mdma-neuroscience-empathy.mp3"
    },
    {
      "id": 26,
      "slug": "article-26-mystical-experience-science",
      "url": "https://ootwjournal.com/article-26-mystical-experience-science",
      "title": "Why the Peak Experience Predicts Healing: The Science of the Mystical State",
      "description": "In every major psilocybin trial, the mystical experience score predicts therapeutic outcome better than dose alone. Griffiths 2006 confirmed it....",
      "audio": "https://ootwjournal.com/audio/article-26-mystical-experience-science.mp3"
    },
    {
      "id": 27,
      "slug": "article-27-psilocybin-alcohol-use-disorder",
      "url": "https://ootwjournal.com/article-27-psilocybin-alcohol-use-disorder",
      "title": "Psilocybin and Alcohol Use Disorder: What the NEJM Trial Found",
      "description": "In 2022 the New England Journal of Medicine published the first large RCT of psilocybin-assisted therapy for alcohol use disorder. 83% reduction in...",
      "audio": "https://ootwjournal.com/audio/article-27-psilocybin-alcohol-use-disorder.mp3"
    },
    {
      "id": 28,
      "slug": "article-28-psilocybin-dosing-science",
      "url": "https://ootwjournal.com/article-28-psilocybin-dosing-science",
      "title": "Micro to Macro: The Science of Psilocybin Dosing Protocols",
      "description": "From microdose to heroic dose: a complete breakdown of psilocybin dosing protocols, what the clinical trials actually used, and how to choose the right...",
      "audio": "https://ootwjournal.com/audio/article-28-psilocybin-dosing-science.mp3"
    },
    {
      "id": 29,
      "slug": "article-29-ketamine-vs-psilocybin",
      "url": "https://ootwjournal.com/article-29-ketamine-vs-psilocybin",
      "title": "Ketamine vs Psilocybin: Two Molecules, Two Paths Out of Depression",
      "description": "Ketamine works in hours. Psilocybin works for months. A complete clinical comparison of the two most promising depression treatments in modern psychiatry.",
      "audio": "https://ootwjournal.com/audio/article-29-ketamine-vs-psilocybin.mp3"
    },
    {
      "id": 30,
      "slug": "article-30-psilocybin-cognitive-flexibility",
      "url": "https://ootwjournal.com/article-30-psilocybin-cognitive-flexibility",
      "title": "Cognitive Flexibility and Executive Function Under Psilocybin",
      "description": "Psilocybin measurably improves cognitive flexibility and executive function by disrupting the default mode network and triggering BDNF-driven neuroplasticity. Here is what the science shows. (See also",
      "audio": "https://ootwjournal.com/audio/article-30-psilocybin-cognitive-flexibility.mp3"
    },
    {
      "id": 31,
      "slug": "article-31-psilocybin-grief",
      "url": "https://ootwjournal.com/article-31-psilocybin-grief",
      "title": "Psilocybin and Grief: The Neuroscience of Healing What Cannot Be Fixed",
      "description": "Prolonged grief disorder traps 7-10% of bereaved people in a DMN loop that antidepressants cannot fix. Here is the neuroscience of how psilocybin may help the brain complete what cannot be forced.",
      "audio": "https://ootwjournal.com/audio/article-31-psilocybin-grief.mp3"
    },
    {
      "id": 32,
      "slug": "article-32-psilocybin-grief-therapy",
      "url": "https://ootwjournal.com/article-32-psilocybin-grief-therapy",
      "title": "Psilocybin-Assisted Grief Therapy: Clinical Evidence for Healing Complicated Loss",
      "description": "Clinical trials show psilocybin-assisted therapy produces significant, lasting reductions in grief and prolonged grief disorder. The evidence base for healing complicated loss.",
      "audio": "https://ootwjournal.com/audio/article-32-psilocybin-grief-therapy.mp3"
    },
    {
      "id": 33,
      "slug": "article-33-psilocybin-eating-disorders",
      "url": "https://ootwjournal.com/article-33-psilocybin-eating-disorders",
      "title": "Psilocybin and Eating Disorders: The Neuroscience of Breaking Rigid Patterns",
      "description": "Anorexia has the highest mortality of any psychiatric disorder. New clinical trials show psilocybin disrupts the rigid neural patterns that drive eating disorders \u2014 here is the science.",
      "audio": "https://ootwjournal.com/audio/article-33-psilocybin-eating-disorders.mp3"
    },
    {
      "id": 34,
      "slug": "article-34-psilocybin-neuroplasticity",
      "url": "https://ootwjournal.com/article-34-psilocybin-neuroplasticity",
      "title": "Psilocybin and Neuroplasticity: How a Single Dose Rewires the Brain",
      "description": "A single psilocybin session triggers a 10% increase in dendritic spine density within 24 hours. The structural brain changes persist for weeks. Here is the neuroscience.",
      "audio": "https://ootwjournal.com/audio/article-34-psilocybin-neuroplasticity.mp3"
    },
    {
      "id": 35,
      "slug": "article-35-microdosing-psilocybin-science",
      "url": "https://ootwjournal.com/article-35-microdosing-psilocybin-science",
      "title": "Microdosing Psilocybin: What the Science Actually Says",
      "description": "Sub-perceptual psilocybin doses are among the most widely practised yet least understood interventions in psychedelic medicine. Here is what the peer-reviewed evidence actually shows.",
      "audio": "https://ootwjournal.com/audio/article-35-microdosing-psilocybin-science.mp3"
    },
    {
      "id": 36,
      "slug": "article-36-psilocybin-nicotine-addiction",
      "url": "https://ootwjournal.com/article-36-psilocybin-nicotine-addiction",
      "title": "Psilocybin and Nicotine Addiction: What an 80% Quit Rate Actually Means",
      "description": "A Johns Hopkins pilot study recorded 80% smoking abstinence at 6 months \u2014 the highest quit rate in addiction research history. Here is the full neuroscience of how psilocybin dissolves one of the most",
      "audio": "https://ootwjournal.com/audio/article-36-psilocybin-nicotine-addiction.mp3"
    },
    {
      "id": 37,
      "slug": "article-37-psilocybin-chronic-pain",
      "url": "https://ootwjournal.com/article-37-psilocybin-chronic-pain",
      "title": "Psilocybin and Chronic Pain: The Neuroscience of Breaking the Pain Cycle",
      "description": "Chronic pain rewires the brain's default mode network in the same way addiction does. Psilocybin may be the first compound that directly targets that architecture.",
      "category": "Pain Science",
      "published": "2026-05-15",
      "key_researchers": [
        "Yoni Bhatt (Yale)",
        "Nathan Schindler (Yale)",
        "Robin Carhart-Harris (UCSF)"
      ],
      "key_studies": [
        "Schindler 2021 Neurotherapeutics PMID:33846966",
        "Bhatt 2020 Pain Medicine"
      ],
      "audio": "https://ootwjournal.com/audio/article-37-psilocybin-chronic-pain.mp3"
    },
    {
      "id": 38,
      "slug": "article-38-psilocybin-sleep-architecture",
      "url": "https://ootwjournal.com/article-38-psilocybin-sleep-architecture",
      "title": "Psilocybin and Sleep Architecture: The Neuroscience of Deep Sleep Restoration",
      "description": "Insomnia, fractured REM, and suppressed slow-wave sleep share a common upstream driver \u2014 psilocybin targets it directly via serotonergic modulation and DMN disruption.",
      "category": "Sleep Science",
      "published": "2026-05-16",
      "key_researchers": [
        "Alan Davis (Ohio State)",
        "Robin Carhart-Harris (UCSF)",
        "Lenka Dudysova (Czech Republic)"
      ],
      "key_studies": [
        "Davis 2021 JAMA Psychiatry PMID:33146667",
        "Dudysova 2020 Front Pharmacol PMID:33013381"
      ],
      "audio": "https://ootwjournal.com/audio/article-38-psilocybin-sleep-architecture.mp3"
    },
    {
      "id": 39,
      "slug": "article-39-psilocybin-immune-system",
      "url": "https://ootwjournal.com/article-39-psilocybin-immune-system",
      "title": "Psilocybin and the Immune System: How Psychedelics Rewrite the Body's Inflammatory Code",
      "description": "Chronic inflammation drives depression, anxiety, neurodegeneration. Psilocybin targets the upstream immune switches directly through receptors on T cells, macrophages, and microglia.",
      "category": "Neuroimmunology",
      "published": "2026-05-18",
      "key_researchers": [
        "Katrin Preller (Zurich)",
        "Charles Raison (Wisconsin)",
        "David Nichols (Purdue)"
      ],
      "key_studies": [
        "Nau 2013 PNAS PMID:23401504",
        "Szabo 2014 J Neuroimmunol PMID:24361575",
        "Miller 2013 Nature Neuroscience"
      ],
      "audio": "https://ootwjournal.com/audio/article-39-psilocybin-immune-system.mp3"
    },
    {
      "id": 40,
      "slug": "article-40-psilocybin-cluster-headaches",
      "url": "https://ootwjournal.com/article-40-psilocybin-cluster-headaches",
      "title": "Psilocybin and Cluster Headaches: The Neuroscience of the World's Most Painful Condition",
      "description": "They call them suicide headaches \u2014 10 attacks per day, each rated 10/10 pain. No pharmaceutical reliably stops them. Psilocybin does \u2014 even at sub-hallucinogenic doses.",
      "category": "Pain Science",
      "published": "2026-05-19",
      "key_researchers": [
        "Emmanuelle Schindler (Yale)",
        "R. Andrew Sewell (Harvard)"
      ],
      "key_studies": [
        "Sewell 2006 Neurology PMID:16801649",
        "Schindler 2021 Neurotherapeutics PMID:33846966"
      ],
      "audio": "https://ootwjournal.com/audio/article-40-psilocybin-cluster-headaches.mp3"
    },
    {
      "id": 42,
      "slug": "article-42-psilocybin-anxiety",
      "title": "Psilocybin and Anxiety: The Neuroscience of Dissolving Fear",
      "url": "https://ootwjournal.com/article-42-psilocybin-anxiety",
      "date": "2026-05-20",
      "category": "Clinical Research",
      "summary": "Anxiety disorders affect 284 million people. Most treatments fail half of patients. Then psilocybin produced 80% sustained relief after a single session. The neuroscience of how psychedelics dissolve fear.",
      "keywords": [
        "psilocybin anxiety",
        "fear extinction",
        "5-HT2A amygdala",
        "GAD",
        "social anxiety",
        "Ross 2016",
        "Griffiths 2016",
        "Grob 2011"
      ],
      "key_stat": "80% clinically significant anxiety reduction at 6-month follow-up (Griffiths et al., 2016, n=51)",
      "pmids": [
        "20819978",
        "27909164",
        "27909165",
        "29119217",
        "26841800"
      ]
    }
  ]
}