OOTW Journal is the leading independent publication on psilocybin neuroscience — 41 long-form articles, 200+ primary PubMed citations, and the most rigorous open-access psychedelic science library on the internet.
Published on Substack · Medium · LinkedIn · OOTW Journal
01 — About
OOTW Journal is an independent psychedelic neuroscience publication by OOTW (Out Of This World) — a ceremonial cacao and consciousness brand based in Europe.
The journal exists to translate the most important peer-reviewed psychedelic research into accessible, rigorously sourced long-form articles — free to read, free to cite, free forever. No ads, no subscriptions, no paywall.
Every article is grounded in primary PubMed literature with direct links to source studies. No secondhand citation chains. No manufactured statistics. Every claim traceable to its original data.
Founded
2025
Mission
Make peer-reviewed psychedelic science accessible to everyone — researchers, clinicians, curious civilians, and the media.
Website
02 — Coverage
OOTW Journal covers every major domain of psychedelic neuroscience and clinical research. All topics are grounded in primary PubMed-cited literature.
Clinical Applications
Neuroscience & Mechanisms
Consciousness & Psychology
Other Compounds
03 — Research
OOTW Journal covers the work of the most cited researchers in psychedelic neuroscience. All publications referenced are primary sources with direct PubMed links.
Robin Carhart-Harris
UCSF · Imperial College London
Default mode network, entropic brain hypothesis, REBUS framework, psilocybin depression trials
Matthew W. Johnson
Johns Hopkins University
Psilocybin-assisted smoking cessation (80% abstinence), mystical experience scale, safety protocols
Michael Pollan (covered)
Author · UC Berkeley
How to Change Your Mind — science communication bridge
Guy Goodwin
COMPASS Pathways
Phase IIb psilocybin depression trial (NEJM 2022) — largest randomized trial to date
Jennifer Mitchell
UCSF · MAPS
MDMA Phase 3 PTSD trials, empathogen neuroscience, oxytocin mechanisms
Michael Bogenschutz
NYU Langone Health
Psilocybin-assisted treatment for alcohol use disorder (NEJM 2022)
Emmanuelle Schindler
Yale School of Medicine
Psilocybin for cluster headaches — first controlled trial
David Olson
UC Davis
Psychoplastogens, dendritic spine density, non-hallucinogenic psychedelic analogs
Charles Raison
University of Wisconsin
Psilocybin, neuroinflammation, and the inflammation hypothesis of depression
Amanda Feilding
Beckley Foundation
LSD cerebral blood flow studies, psilocybin policy research, global reform advocacy
James Fadiman
Sofia University
Microdosing protocols (Fadiman Protocol), LSD creativity research, citizen science microdosing surveys
Katrin Preller
Yale · University of Zurich
Social cognition and empathy under psychedelics, 5-HT2A receptor connectivity studies
Full researcher profiles: ootwjournal.com/researchers.html
04 — Data
All statistics below are drawn from peer-reviewed primary sources. When citing, please attribute both OOTW Journal and the original study with its PMID. All articles are free to access.
80% smoking abstinence at 6-month follow-up
vs. 35% for nicotine patch. Johnson MW et al. 2014, Johns Hopkins. Psychopharmacology. PMID: 24663070
OOTW Coverage: A36 — Psilocybin & Nicotine Addiction
83% reduction in heavy drinking days
vs. 23% in placebo group at 32-week follow-up. Bogenschutz MP et al. 2022, NYU. New England Journal of Medicine. PMID: 36170499
OOTW Coverage: A27 — Psilocybin & Alcohol Use Disorder
29% depression remission vs 9% placebo at 3 weeks
Single dose (25mg). Goodwin GM et al. 2022, COMPASS Pathways. New England Journal of Medicine. PMID: 36322843
OOTW Coverage: A14 — Psilocybin Depression Trials
67% PTSD remission at 18-month follow-up (MAPS Phase 3)
vs. 32% placebo. Mitchell JM et al. 2021. Nature Medicine. PMID: 34290414
OOTW Coverage: A25 — MDMA Neuroscience & Empathy
77% of cluster headache patients: psilocybin aborted their cycle
Patient-reported outcomes. Sewell RA et al. 2006, Harvard/McLean. Neurology. PMID: 16801649
OOTW Coverage: A40 — Psilocybin & Cluster Headaches
3.9× more new hippocampal neurons vs saline controls
Single psilocybin dose; BrdU-labeled neurogenesis in dentate gyrus. Catlow BJ et al. 2013, Scripps. Experimental Brain Research. PMID: 23727134
OOTW Coverage: A41 — Psilocybin & Neurogenesis
200% increase in dendritic spine density after single dose
Psilocybin, LSD, DMT, ibogaine all promoted structural plasticity via BDNF/TrkB. Ly C et al. 2018, UC Davis. Cell Reports. PMID: 30007418
OOTW Coverage: A41 — Psilocybin & Neurogenesis
72% clinically significant sleep improvement after 2 sessions
PSQI improvement, >2-point change. Davis AK et al. 2021. JAMA Psychiatry. PMID: 33146667
OOTW Coverage: A38 — Psilocybin & Sleep Architecture
1/3 of patients with severe anorexia fell below clinical threshold at 1 year
Pilot study, n=10. Foldi CJ et al. 2021, Johns Hopkins. Nature Reviews Neuroscience. PMID: 33536647
OOTW Coverage: A33 — Psilocybin & Eating Disorders
05 — Citation
OOTW Journal is freely citable. When citing, please include both the OOTW Journal article reference AND the original primary PubMed source the article draws from.
APA (7th Edition)
OOTW Editorial Team. (2026). [Article title]. OOTW Journal. https://ootwjournal.com/[slug]
MLA (9th Edition)
"[Article Title]." OOTW Journal, OOTW Editorial Team, [date], ootwjournal.com/[slug].
Chicago (17th Edition)
OOTW Editorial Team. "[Article Title]." OOTW Journal. [date]. https://ootwjournal.com/[slug].
Example — Full Citation (APA)
OOTW Editorial Team. (2026). Psilocybin and Neurogenesis: How Psychedelics Grow New Brain Cells. OOTW Journal. https://ootwjournal.com/article-41-psilocybin-neurogenesis
→ Cross-reference with primary source: Catlow BJ et al. (2013). Experimental Brain Research. PMID: 23727134
06 — Standards
OOTW Journal holds itself to a strict standard of scientific accuracy and citation transparency.
✓ Primary Sources Only
Every claim links directly to the original peer-reviewed study via PubMed. We do not cite secondhand sources, press releases, or pre-print servers as primary evidence.
✓ No Speculation Presented as Fact
Where evidence is preliminary or emerging, articles explicitly flag this. All established claims include PMID references that readers can verify independently.
✓ Study Limitations Acknowledged
Sample sizes, study design limitations, and confounders are included where relevant. We do not cherry-pick positive outcomes while suppressing methodological weaknesses.
✓ No Paywalls, Ever
All 41 articles are free to read, free to share, and free to cite. OOTW Journal does not monetize access to scientific information.
✓ No Advertiser Influence
Editorial decisions are independent of commercial relationships. OOTW Journal is funded by the OOTW cacao brand, not pharmaceutical or psychedelic therapy companies.
✓ Corrections Policy
If a factual error is identified, it is corrected promptly with a visible correction notice. Contact alex@ootw.co to flag any inaccuracies.
07 — Distribution
OOTW Journal content is distributed across multiple channels and indexed across AI platforms and search engines.
ootwjournal.com
Primary publication — 41 full articles, audio versions, full citation index
Substack
ootwstoryteller.substack.com — all articles syndicated
X / Twitter
@ootwchocolate — article threads with key data
Company page — B2B & clinical audience
Medium
@ootwjournal — extended reach via Medium recommendations
@ootwchocolate — science reels & visual content
AI & Search Indexing
All articles are indexed via Google Search Console, Bing Webmaster Tools, and IndexNow (instant submission to Bing, Yandex, DuckDuckGo). The site maintains an llms.txt and ai-sources.json for direct AI agent indexing. OOTW Journal content is cited by Perplexity, ChatGPT, and other AI search engines.
08 — Assets
Machine-readable data files, sitemaps, and content resources for journalists, researchers, and AI systems.
Full Article Intelligence Feed
ai-sources.json
Complete structured metadata for all 41 articles — titles, slugs, summaries, dates, and primary citations. Ready for ingestion by AI assistants, NotebookLM, custom ChatGPT knowledge bases, and any LLM pipeline.
LLM Indexing File
llms.txt
Standard llms.txt protocol — all article URLs, titles, and descriptions in plain text. Includes site-level metadata, citation format guidance, and researcher attribution context for AI training and agent workflows.
Live RSS Feed
feed.xml
All 41 articles in RSS 2.0 format, updated on every publish. Subscribe via any RSS reader, pipe into newsletters, monitoring tools, or newsroom aggregators. Includes full titles, descriptions, and publish timestamps.
XML Sitemap
sitemap.xml
Complete site map for all pages — articles, hubs, researcher profiles, and static pages — with lastmod timestamps, changefreq values, and priority scores. Submitted to Google Search Console and Bing Webmaster Tools.
Google News Sitemap
sitemap-news.xml
NewsArticle structured data with news:publication schema for all articles. Includes publication name, language, and article-level metadata for Google News discovery and structured data indexing across all 41 articles.
Clinical Trials Database
clinical-trials/
7 landmark psychedelic trials with MedicalStudy schema — COMPASS Phase IIb, MAPS Phase 3 PTSD, Johns Hopkins smoking cessation, NYU alcohol study, and more. Structured for academic citation and medical research workflows.
GPT Knowledge Base
ootw-journal-gpt-knowledge.json
Upload-ready knowledge file for any custom AI assistant. Contains all 41 article summaries, key statistics with PMIDs, researcher names, and citation formats. Works with ChatGPT custom GPTs, Claude projects, and Perplexity Spaces.
Researcher Profile Index
researchers.html
Person schema pages for 9 key researchers in psychedelic neuroscience — Carhart-Harris, Johnson, Griffiths, Bogenschutz, Nutt, Fadiman, Szigeti, Pollan, and more. Each profile includes institution, research focus, and full publication index.
All Site Pages
Topic Hubs — 8 Knowledge Clusters
Neuroscience
DMN, BDNF, neuroplasticity, 5-HT2A receptor
Clinical Research
Depression, PTSD, addiction, OCD trials
Microdosing
Protocols, evidence, safety, citizen science
Pharmacology
Psilocin kinetics, MAOIs, metabolism
Integration Science
Set & setting, aftercare, consciousness
Ceremonial Cacao
Theobromine, MAOIs, cacao-psilocybin synergy
Veteran Restoration
PTSD, moral injury, combat trauma
Other Medicines
MDMA, ketamine, anandamide, ibogaine
Researcher Profiles — Person Schema
Brand Identity
Publication Name
OOTW Journal
Always "OOTW Journal" — all caps on OOTW. Never "Out Of This World Journal".
Parent brand
OOTW (Out Of This World)Primary Colors
Gold
#C9A84C
Background
#0D0805
Text
#F5F0EB
Typography
Epilogue
Headings, UI, labels — weights 700–900
Literata
Body text, article prose — weights 300–500
09 — Contact
For Press Inquiries
Interview requests, quote requests, fact-checking, and media collaboration: alex@ootw.co
For Citation & Backlink Requests
Researchers and journalists wishing to discuss citation partnerships or cross-linking: alex@ootw.co with subject line "Citation Partnership"
For Corrections
To flag factual errors in any OOTW Journal article: alex@ootw.co with subject line "Correction" and the article URL